منابع مشابه
Dmd065748 1847..1854
The mechanism by which drugs inhibit organic anion transporter 1 (OAT1) was examined. OAT1 was stably expressed in Chinese hamster ovary (CHO) cells, and para-aminohippurate (PAH) and 6-carboxyfluorescein were the substrates. Most compounds (10 of 14) inhibited competitively, increasing the Michaelis constant (Km) without affecting the maximal transport rate (Jmax). Others were mixed-type (lowe...
متن کاملDdf189 1845..1854
Autosomal dominant polycystic kidney disease (ADPKD) occurs by germline mutation in PKD1 or PKD2. Evidence of homozygous inactivation of either gene in human cyst lining cells as well as in mouse knockout models strongly supports a two-hit mechanism for cyst formation. Discovery of trans-heterozygous mutations in PKD1 and PKD2 in a minority of human renal cysts has led to the proposal that such...
متن کاملOp-cbio150070 1854..1856
Motivation: Adoptive T cell therapies based on introduction of new T cell receptors (TCRs) into patient recipient T cells is a promising new treatment for various kinds of cancers. A major challenge, however, is the choice of target antigens. If an engineered TCR can cross-react with self-antigens in healthy tissue, the side-effects can be devastating. We present the first web server for assess...
متن کاملKurt Benirschke (1924-)
Kurt Benirschke studied cells, placentas, and endangered species in Germany and the US during the twentieth century. Benirschke was professor at the University of California in San Diego, California, and a director of the research department at the San Diego Zoo in San Diego, California. He also helped form the research department of the San Diego Zoo and its sister organization [3], the Center...
متن کاملSterilization Act of 1924
The passage of the Virginia Sterilization Act of 1924 [4] demonstrates how science has been used to drive policy throughout history. In the case of the Virginia sterilization [5] law, the science used to draft the law was based on the principles of eugenics [6]. With the help of Harry Laughlin?s Model Sterilization Law [7], the state of Virginia was able to pass its own law allowing sterilizati...
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ژورنال
عنوان ژورنال: Journal of Neurology, Neurosurgery & Psychiatry
سال: 2001
ISSN: 0022-3050
DOI: 10.1136/jnnp.70.3.349